for example Dextromethorphan always is HBr or Pseudoephedrine is other HCL or Codeine is either sulfate or phosphate. is it for time release or what. does one brackish dissolve faster or does one last longer is it for that (duration)?Why do medication hold different salt.?
If I remember correctly, it have to do with chemical stability. For example Pseudoephedrine (the chemical) may be intensely unstable itself. But if a hydrochloride molecule is added on, it may increase it's stability and solubility in sure compounds.
It is usually a function of solubility. A salt near a higher solubility is recurrently chosen to optimize bioavailability. Sometimes it is a matter of preparative chemistry: one exceptional salt may be easier or cheaper to isolate.
reactivity, solubility, reliability, upset stomach prevention
the answers on top are correct but also it depends where on earth the absorption of the drug is intended to bear place!
a good example as you said, pseudoephedrines is contained by HCl.
water soluble drugs are confidently absorbed surrounded by thier unionised form!!
Alkali Drugs are not absorbed within the stomoch because they become ionised in the bitter condition, but they do get obsessed in the S.intestine where on earth they remain in thier unionised form, because the S.intestine is alkali and does not Ionise the Drug,
surrounded by the stomach the drug would be would be acidic and within the s.intestine it would be alkali,
it all depends where on earth the drug is ment to be absorbed!!.
hope this help!!
how come more salt dont own medication
Monday, September 27, 2010
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment