Why does amphotericin B have severe side effects contained by humans?

Why does amphotericin B have severe side effects contained by humans?
Amphotericin B is associated with renal toxicity. It is impressive if on Ampho to be recieving adequate hydration to flush the kidneys. It also is associated near a relatively high rate of anaphylactic (severe allergic) reaction. However, the Amphotericin B used now is much smaller number likely to result in problems than its older age group counterpart (although it does still make me agitated when I have to make a contribution it to patients!)
Keeping in mind that any medication is a foreign substance surrounded by your body and can cause side effects, Amphotericin B interacts beside about three dozen adjectives medications. The most severe (relative) side effect is renal breakdown. Amphotericin B should only be used for the treatment of potentially life-threatening fungal infections and not to treat smaller number serious fungal infections of the mouth, throat, or vagina in patients next to a normal immune system, which tell you something right there.